My first thought comes to one of the first missions of the game with Maelstrom, between Royce and Brick.
I usually save Brick in that mission and I could picture him playing a role like Wrex from Mass Effect. One of the biggest leaders of Malestrom, their gang now bigger and nastier than ever, no one wants to fuck with them. Brick is in charge, and when V shows up, ready to draw guns again, Brick appears and he gives you that big tough guy respect like how Wrex did, saying this is the crazy motherfucker who saved my life and proceeded to blow up half of Night City afterwards.
There’s so many small things I could picture being different in the sequel. I hope this will be the case since even The Witcher 3 had some pretty significant changes to the story depending on the options you chose about what happened in The Witcher 2.
Personally I’d like to see some results from all that cyberpsychosis research. Perhaps they find a way to recondition them on a large scale, like the trailer psycho lady who got recruited into maxtac (I’m still mad she doesn’t drop her real, special mantis blades).
I’d also like to see all the changes we set in motion as V: which ending will be canon, what happens to dogtown and Pacifica (is to be sold to kang tao), more on the blue eyed people (AI? aliens?) that are teased at several times, etc.
I’m fairly open to whatever story and content they decide to make as long as it remains as atmospheric and compelling as the 77 setting.