Vampire Hunter D: Bloodlust (吸血鬼ハンターD ブラッドラスト) is a 2000 dark fantasy vampire adventure anime film. It was written, directed and storyboarded by Yoshiaki Kawajiri, with Yutaka Minowa designing the characters, Yūji Ikehata serving as art director and designing the setting, and Marco D’Ambrosio composing the music.
The film is based on the third novel of Hideyuki Kikuchi’s Vampire Hunter D series, Demon Deathchase.
According to Wikipedia:
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I don’t know if this was done in an effort to appeal more to Western audiences and increase chances of an overseas box office success, or for artistic reasons (the setting is much more Western- than Eastern-influenced). Either way it was an interesting production choice.