My understanding is by medical standards, the evidence is pretty low quality, which is why GnRH agonists aren’t approved by the EMA, MHRA, FDA, or NICE for gender dysphoria.
It highlights a wider issue in medicine though, the obsession with randomised controlled trials, which is basically the only evidence the GRADE method considers “high quality”. We are seeing exactly the same problem with MDMA assisted therapy, any therapy where blinding is difficult is dismissed by the medical establishment. NICE dismissed (es)ketamine for depression for the same reason. Add to that the fact that GnRH agonists are off patent, so there’s no incentive for industry to fund studies.
My understanding is by medical standards, the evidence is pretty low quality,
Your understanding is wrong and influenced by transphobic rhetoric, not “medical standards”, which have considered puberty blockers safe and effective since at least the 1980s.
The use of puberty blockers is supported by twelve major American medical associations, including the American Medical Association,[14] the American Psychological Association,[15] and the American Academy of Pediatrics.[16] the American Academy of Child and Adolescent Psychiatry,[17] the Pediatric Endocrine Society,[18] the American College of Obstetricians and Gynecologists,[19] the American Association of Clinical Endocrinologists,[20] and the American College of Physicians.[21] In Australia four medical organizations support them,[22] as does the Endocrine Society,[23] and the World Professional Association for Transgender Health (WPATH).[24]
Overall, puberty blockers have demonstrated an excellent safety and efficacy profile in the treatment of precocious puberty. The most common side effects reported include nonspecific headaches, hot flashes, and implant-related skin reactions.[39]
E: and before you try throwing bone density at me, most of the people impacted are cis (and will not be stopped from taking blockers), and either way, there is simple treatment to counteract this minor issue (and which is completely insignificant when compered to the alternative). The ban is 100% motivated by transphobia and cruelty.
We’re not talking about the use of puberty blockers in cases of precocious puberty, we’re talking about them in cases where they’d block typical puberty in cases of gender dysphoria.
My understanding is by medical standards, the evidence is pretty low quality, which is why GnRH agonists aren’t approved by the EMA, MHRA, FDA, or NICE for gender dysphoria.
It highlights a wider issue in medicine though, the obsession with randomised controlled trials, which is basically the only evidence the GRADE method considers “high quality”. We are seeing exactly the same problem with MDMA assisted therapy, any therapy where blinding is difficult is dismissed by the medical establishment. NICE dismissed (es)ketamine for depression for the same reason. Add to that the fact that GnRH agonists are off patent, so there’s no incentive for industry to fund studies.
Your understanding is wrong and influenced by transphobic rhetoric, not “medical standards”, which have considered puberty blockers safe and effective since at least the 1980s.
source
E: and before you try throwing bone density at me, most of the people impacted are cis (and will not be stopped from taking blockers), and either way, there is simple treatment to counteract this minor issue (and which is completely insignificant when compered to the alternative). The ban is 100% motivated by transphobia and cruelty.
We’re not talking about the use of puberty blockers in cases of precocious puberty, we’re talking about them in cases where they’d block typical puberty in cases of gender dysphoria.