Unfortunately, I inherited ProofPoint Essentials. What all do you use (and like!). At my last job we used Avanan across the board and I LOVED their setup. Nearly no false positives/negatives.
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We use ProofPoint but exploring other options. I have heard very good things about Avanan but have never trialed it. We’re big Sophos partners as well and they recently revamped their email security service, so we’re going to at least give it a go given the integration with their other offerings.