If I want to install and use a different desktop environment than came with my distro, what (if any) problems can I expect to encounter?
I currently use Debian with GNOME and I want an optimised system for music production and graphic design. As far as I can tell, the two main options I have are to make some tweaks to my current system’s configuration (rt kernel, swap use, cpu behaviour and others) or to switch to a dedicated media distro which is configured already. The creative distros that I like the look of don’t use GNOME though.
Which option will be easiest for me?
What optimizations are you wanting? Chances are you don’t need a specialty distro. Those distros are often pretty obscure and maintained by only a few people.
If I want to install and use a different desktop environment than came with my distro, what (if any) problems can I expect to encounter?
I’m not knowledgeable about kernel tweaks, but switching DEs is very easy on Debian and should not cause any problems. Just install the desktop metapackage (e.g., “task-kde-desktop”) and you’ll be able to choose it from the login screen.
There will be some theming goofiness but that is easily fixable.
If you’re not comfortable mucking with the kernel: Install a dedicated media distro and add whichever DE you prefer. Otherwise, sticking with Debian will likely be more convenient.