This might be situation dependant, but I personally (Ender 3 S1 Pro) spent weeks searching for ready-made firmware, then learning how to modify and compile firmware, then troubleshooting why I couldn’t get Linear Advance working, only to finally figure out that it just plain wasn’t supported by Marlin on my hardware.

I was about to give up and just go back to the stock Creality firmware, but decided to give Klipper a go without really knowing the full capabilities, other than that it natively supported Pressure Advance. In a fraction of the time I had spent dicking around trying to get a single feature enabled in Marlin, I had my printer running off a slick web interface, fully tuned up and printing substantially better than I was able to achieve with Marlin.

Now, granted, I never tried to get up and running with Octoprint so I probably am only half answering your question, but as a relatively casual printer I have found using and tweaking Klipper to be substantially more straightforward, and would not hesitate to recommend giving it a stab as long as you have a RPi laying around already.